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Unfortunately, there are few studies that have examined this question specifically, and even fewer that have explored the question of whether T4 or T3 (and which type of each) would be the best choice.

The few studies that have been done produced mixed results.

In other words, T3 levels are low because the body is attempting to conserve energy and resources to better cope with the challenges it is facing.

Increasing thyroid hormone levels in this situation could conceivably have adverse effects.

For example, the changes observed in the thyroid axis in acute illness are similar to those observed in fasting, which can be interpreted as an attempt to reduce energy expenditure and protein wasting.

(1) Giving fasting subjects thyroid hormone results in increased catabolism (breakdown).