Which agent is a nonsedating antihistamine

30 Jan

Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating.

However, high doses can still induce drowsiness through acting on the central nervous system.

This parameter is particularly pertinent to CIU, as evidenced by O'Donnell et al9 whose analysis of a disease-specific, purpose-designed questionnaire and the Nottingham Health Profile demonstrated that patients with chronic urticaria experienced considerable disability, handicap, and reduced QOL.

Part 1 of the health profile showed that patients were restricted in areas of mobility, sleep, and energy and experienced pain, social isolation, and altered emotional reactions.

Histamine receptors exhibit constitutive activity, so antihistamines can function as either a neutral receptor antagonist or an inverse agonist at histamine receptors.

Although people typically use the word “antihistamine” to describe drugs for treating allergies, doctors and scientists use the term to describe a class of drug that opposes the activity of histamine receptors in the body.-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing) as well as for insomnia.

They are sometimes also used to treat motion sickness or vertigo caused by problems with the inner ear.

Using the validated Dermatology Life Quality Index (DLQI), a survey of 170 consecutive patients had results that showed that patients with CIU experienced greater QOL impairment than outpatients with either psoriasis, acne, or vitiligo and experienced a comparable level of impairment to patients with severe atopic dermatitis.10 Because of CIU's devastating effect on health-related QOL and the discomfort of CIU, appropriate treatment selection is crucial.

The ideal treatment for CIU would not only rid the patient of the wheals, edema, and pruritus that characterize the condition but also improve QOL.